Letrozole is a medication that belongs to a class of drugs known as aromatase inhibitors. It is primarily used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. Letrozole works by blocking the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) to estrogens (female hormones) in the body. By inhibiting this process, letrozole reduces the amount of estrogen in the body, which can help slow or stop the growth of certain types of breast cancer. Letrozole is available in tablet form and is taken orally.

How Does Letrozole Work?

Letrozole works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) to estrogens (female hormones) in the body. This process occurs in various tissues throughout the body, including adipose tissue, muscle, liver, and breast tissue.

In postmenopausal women, the majority of estrogen in the body is produced by the aromatization of androgens in peripheral tissues. By blocking this process, letrozole reduces the amount of estrogen in the body, which can help slow or stop the growth of certain types of breast cancer that are dependent on estrogen for their growth. Letrozole is classified as an aromatase inhibitor and is commonly used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women.

Dosage and Administration of Letrozole

The recommended dosage of letrozole for breast cancer treatment varies depending on the specific patient’s condition and medical history. In general, the recommended dose for postmenopausal women with early-stage, hormone receptor-positive breast cancer is 2.5 mg once daily, taken orally.

Treatment with letrozole is usually continued for five years or until the cancer recurs, whichever comes first. For advanced breast cancer, the dosage may be higher or adjusted by a healthcare professional. Letrozole should be taken at the same time each day, with or without food. If a dose is missed, it should be taken as soon as possible, unless it is almost time for the next dose. In this case, the missed dose should be skipped and the regular dosing schedule resumed.

Letrozole should be used with caution in patients with liver or kidney disease, and the dosage may need to be adjusted accordingly. The dosage and duration of treatment should be determined by a healthcare professional, and patients should not adjust the dose or stop taking the medication without first consulting with their healthcare provider.

Side Effects of Letrozole

Like all medications, letrozole can have potential side effects. The most common side effects of letrozole include:

• Hot flashes
• Fatigue
• Joint pain
• Headaches
• Nausea
• Muscle pain
• Increased sweating
• Insomnia

More serious side effects of letrozole can include:

• Bone loss (osteoporosis)
• Increased risk of fractures
• Increased cholesterol levels
• Liver problems
• Cardiovascular problems
• Endometrial cancer (rare)

It is important to seek medical attention if any of these side effects occur while taking letrozole or any other medication.

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